ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2017, Vol. 48 ›› Issue (11): 2015-2022.doi: 10.11843/j.issn.0366-6964.2017.11.002

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Progress of Recombinant Duck Enteritis Virus-vectored Vaccines

MA Yun-chao1,2,3, CHENG An-chun1,2,3*, WANG Ming-shu1,2,3*, WU Ying1,2,3   

  1. 1. Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;
    2. Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;
    3. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
  • Received:2017-05-05 Online:2017-11-23 Published:2017-11-23

Abstract:

Recombinant virus-vectored vaccine is a newly developed vaccine based on viral vectors delivering protective antigens of other pathogens. It can infect host cells and deliver antigen protein encoded by exogenous genes, stimulating both humoral and cellular immune responses. Duck enteritis virus (DEV) has a large genome about 160 kb in length, containing large amounts of non-encoding region and nonessential replication region. Recombinant genetic engineering techniques have brought forward a leap in molecular biology study of DEV and designing DEV-vectored vaccines. Recent studies have demonstrated that DEV may be a promising viral vector candidate and plays a crucial role in future vaccine development. In this review, we summarized the advances of studies on recombinant DEV-vectored vaccines to provide some valuable fundamental information for future DEV vaccine development.

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